InnateDB Protein
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IDBP-59198.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBAP1
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Protein Name
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ubiquitin associated protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368484
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InnateDB Gene
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IDBG-59194 (UBAP1)
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Protein Structure
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Function |
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2. {ECO:0000269PubMed:21757351, ECO:0000269PubMed:22405001}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:21757351}. Endosome {ECO:0000269PubMed:21757351}. Note=Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas. {ECO:0000269PubMed:11599797}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0015031
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protein transport
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GO:0043162
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ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR009060
UBA-like
IPR015940
Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00165
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NZ09
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PhosphoSite |
PhosphoSite-Q9NZ09
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51271
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UniGene |
Hs.739972
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RefSeq |
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HUGO |
HGNC:12461
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OMIM |
609787
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CCDS |
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HPRD |
15597
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IMGT |
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EMBL |
AF222043
AK074724
AK074745
AK074812
AK074969
AK074995
AK223235
AK295482
AK303711
AL136733
AL353662
BC020950
BC098141
BC098316
BC099726
BC100668
CH471071
CR533551
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GenPept |
AAF37827
AAH20950
AAH98141
AAH98316
AAH99726
AAI00669
BAC11162
BAC11176
BAC11224
BAC11323
BAC11342
BAD96955
BAH12084
BAH14025
CAB66667
CAG38582
CAI15914
CAI15915
EAW58467
EAW58468
EAW58469
EAW58470
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