Version 5.4
Homo sapiens Protein: UBAP1
Summary
InnateDB Protein IDBP-59200.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBAP1
Protein Name ubiquitin associated protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000352541
InnateDB Gene IDBG-59194 (UBAP1)
Protein Structure
UniProt Annotation
Function Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2. {ECO:0000269PubMed:21757351, ECO:0000269PubMed:22405001}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:21757351}. Endosome {ECO:0000269PubMed:21757351}. Note=Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas. {ECO:0000269PubMed:11599797}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043130 ubiquitin binding
Biological Process
GO:0015031 protein transport
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Cellular Component
GO:0000813 ESCRT I complex
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
PFAM
PRINTS
PIRSF
SMART SM00165
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZ09
PhosphoSite PhosphoSite-Q9NZ09
TrEMBL
UniProt Splice Variant
Entrez Gene 51271
UniGene Hs.739972
RefSeq
HUGO HGNC:12461
OMIM 609787
CCDS CCDS6550
HPRD 15597
IMGT
EMBL AF222043 AK074724 AK074745 AK074812 AK074969 AK074995 AK223235 AK295482 AK303711 AL136733 AL353662 BC020950 BC098141 BC098316 BC099726 BC100668 CH471071 CR533551
GenPept AAF37827 AAH20950 AAH98141 AAH98316 AAH99726 AAI00669 BAC11162 BAC11176 BAC11224 BAC11323 BAC11342 BAD96955 BAH12084 BAH14025 CAB66667 CAG38582 CAI15914 CAI15915 EAW58467 EAW58468 EAW58469 EAW58470

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca