Version 5.4
Homo sapiens Protein: TPH1
Summary
InnateDB Protein IDBP-592346.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPH1
Protein Name tryptophan hydroxylase 1
Synonyms TPRH; TRPH;
Species Homo sapiens
Ensembl Protein ENSP00000436081
InnateDB Gene IDBG-34418 (TPH1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016597 amino acid binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0008152 metabolic process
GO:0009072 aromatic amino acid family metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR002912 ACT domain
IPR019774 Aromatic amino acid hydroxylase, C-terminal
PFAM PF01842
PF00351
PRINTS PR00372
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PR49
UniProt Splice Variant
Entrez Gene 7166
UniGene Hs.668317
RefSeq
HUGO HGNC:12008
OMIM 191060
CCDS
HPRD 01846
IMGT
EMBL AC055860 EU796639 EU796644 EU796649
GenPept ACE96133 ACE96138 ACE96143

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca