Version 5.4
Homo sapiens Protein: ABCC12
Summary
InnateDB Protein IDBP-592413.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCC12
Protein Name ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000434510
InnateDB Gene IDBG-29697 (ABCC12)
Protein Structure
UniProt Annotation
Function Probable transporter. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000255PROSITE- ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441}.
Disease Associations
Tissue Specificity Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells. {ECO:0000269PubMed:11483364, ECO:0000269PubMed:11688999, ECO:0000269PubMed:12011458}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001140 ABC transporter, transmembrane domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00664
PF13748
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96J65
PhosphoSite PhosphoSite-Q96J65
TrEMBL E9PHY2
UniProt Splice Variant
Entrez Gene 94160
UniGene Hs.739271
RefSeq
HUGO HGNC:14640
OMIM 607041
CCDS
HPRD 06128
IMGT
EMBL AC096996 AF395908 AF395909 AF411577 AF411578 AY040220 AY196326 BC036378
GenPept AAK76740 AAL79528 AAL79529 AAL99900 AAL99901 AAO40749

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca