Homo sapiens Gene: ABCC12
Summary
InnateDB Gene IDBG-29697.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCC12
Gene Name ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140798
Encoded Proteins
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:48082973-48156018
Strand Reverse strand
Band q12.1
Transcripts
ENST00000311303 ENSP00000311030
ENST00000497206 ENSP00000431232
ENST00000534418 ENSP00000431354
ENST00000529084 ENSP00000434510
ENST00000532494 ENSP00000437047
ENST00000529504 ENSP00000433333
ENST00000532355
ENST00000526251
ENST00000533185
ENST00000528693
ENST00000533639 ENSP00000435715
ENST00000527640 ENSP00000436647
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
ABC transporters pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96J65
TrEMBL E9PHY2
UniProt Splice Variant
Entrez Gene 94160
UniGene Hs.410111 Hs.739271
RefSeq NM_033226
HUGO HGNC:14640
OMIM 607041
CCDS CCDS10730
HPRD 06128
IMGT
EMBL AC096996 AF395908 AF395909 AF411577 AF411578 AY040220 AY196326 BC036378
GenPept AAK76740 AAL79528 AAL79529 AAL99900 AAL99901 AAO40749
RNA Seq Atlas 94160