InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUDT4

Summary

InnateDB Protein

IDBP-592420.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT4

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 4

Synonyms

DIPP2; DIPP2alpha; DIPP2beta;

Species

Homo sapiens

Ensembl Protein

ENSP00000449552

InnateDB Gene

IDBG-51175 (NUDT4)

Protein Structure

UniProt Annotation

Function

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269PubMed:10777568}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12121577}.

Disease Associations

Tissue Specificity

Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney. {ECO:0000269PubMed:10777568}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity
GO:0016787	hydrolase activity
GO:0030515	snoRNA binding
GO:0046872	metal ion binding
GO:0052840	inositol diphosphate tetrakisphosphate diphosphatase activity
GO:0052843	inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
GO:0052844	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
GO:0052845	inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
GO:0052846	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
GO:0052847	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO:0052848	inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity

Biological Process

GO:0008152	metabolic process
GO:0009187	cyclic nucleotide metabolic process
GO:0019722	calcium-mediated signaling
GO:0019935	cyclic-nucleotide-mediated signaling
GO:0035556	intracellular signal transduction
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046831	regulation of RNA export from nucleus
GO:0046907	intracellular transport