InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IDH2

Summary

InnateDB Protein

IDBP-592681.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IDH2

Protein Name

isocitrate dehydrogenase 2 (NADP+), mitochondrial

Synonyms

D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH;

Species

Homo sapiens

Ensembl Protein

ENSP00000446147

InnateDB Gene

IDBG-29824 (IDH2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004450	isocitrate dehydrogenase (NADP+) activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006102	isocitrate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR004790 Isocitrate dehydrogenase NADP-dependent
IPR024084 Isopropylmalate dehydrogenase-like domain

PFAM

PF00180

PRINTS

PIRSF

PIRSF000108

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B4DSZ6

UniProt Splice Variant

Entrez Gene

3418

UniGene

Hs.737985

RefSeq

HUGO

HGNC:5383

OMIM

147650

CCDS

HPRD

00973

IMGT

EMBL

AC087284 AC092769 AK294148 AK299987 AK316388

GenPept

BAG57473 BAG61808 BAH14759