InnateDB Protein
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IDBP-592706.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MMP19
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Protein Name
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matrix metallopeptidase 19
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Synonyms
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MMP18; RASI-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000446776
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InnateDB Gene
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IDBG-39276 (MMP19)
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Protein Structure
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Function |
Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. {ECO:0000269PubMed:10809722, ECO:0000269PubMed:10922468}.
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Subcellular Localization |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
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Disease Associations |
Note=May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.
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Tissue Specificity |
Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99542
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PhosphoSite |
PhosphoSite-Q99542
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
4327
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UniGene |
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RefSeq |
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HUGO |
HGNC:7165
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OMIM |
601807
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CCDS |
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HPRD |
03486
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IMGT |
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EMBL |
AC023055
AK303202
AY706993
BC050368
U37791
U38321
U38322
U38431
X92521
Y08622
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GenPept |
AAB63008
AAB63009
AAC51521
AAC99995
AAH50368
AAT97983
BAG64292
CAA63299
CAA69913
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