InnateDB Protein
|
IDBP-59290.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SAE1
|
Protein Name
|
SUMO1 activating enzyme subunit 1
|
Synonyms
|
AOS1; HSPC140; SUA1; UBLE1A;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000270225
|
InnateDB Gene
|
IDBG-59288 (SAE1)
|
Protein Structure
|
|
Function |
The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269PubMed:10187858, ECO:0000269PubMed:10217437, ECO:0000269PubMed:11451954, ECO:0000269PubMed:11481243, ECO:0000269PubMed:15660128, ECO:0000269PubMed:20164921, ECO:0000269PubMed:9920803}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:11481243}.
|
Disease Associations |
|
Tissue Specificity |
Expression level increases during S phase and drops in G2 phase (at protein level). {ECO:0000269PubMed:11481243}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
56
[view]
|
Protein-Protein |
56
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000011
Ubiquitin/SUMO-activating enzyme E1
IPR000594
UBA/THIF-type NAD/FAD binding fold
IPR009036
Molybdenum cofactor biosynthesis, MoeB
|
PFAM |
PF00899
|
PRINTS |
PR01849
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9UBE0
|
PhosphoSite |
PhosphoSite-Q9UBE0
|
TrEMBL |
M0R286
|
UniProt Splice Variant |
|
Entrez Gene |
10055
|
UniGene |
Hs.620309
|
RefSeq |
NP_005491
|
HUGO |
HGNC:30660
|
OMIM |
613294
|
CCDS |
CCDS12696
|
HPRD |
18010
|
IMGT |
|
EMBL |
AC008532
AC008755
AF046025
AF090385
AF110956
AF161489
AK021978
AK315624
AL560234
BC000344
BC003611
BC018271
BT007290
CH471126
|
GenPept |
AAD12785
AAD23902
AAD24433
AAF29104
AAH00344
AAH03611
AAH18271
AAP35954
BAG37992
BAG51064
EAW57461
EAW57462
EAW57463
|
|
|