InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SAE1

Summary

InnateDB Gene

IDBG-59288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAE1

Gene Name

SUMO1 activating enzyme subunit 1

Synonyms

AOS1; HSPC140; SUA1; UBLE1A

Species

Homo sapiens

Ensembl Gene

ENSG00000142230

Encoded Proteins

IDBP-59290

SUMO1 activating enzyme subunit 1

IDBP-596761

SUMO1 activating enzyme subunit 1

IDBP-382419

SUMO1 activating enzyme subunit 1

IDBP-382421

SUMO1 activating enzyme subunit 1

IDBP-766064

IDBP-762380

IDBP-762798

IDBP-760578

IDBP-762274

IDBP-760671

IDBP-765551

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:47113274-47210636

Strand

Forward strand

Band

q13.32

Transcripts

ENST00000270225	ENSP00000270225
ENST00000392776	ENSP00000440818
ENST00000414294	ENSP00000398818
ENST00000413379	ENSP00000416557
ENST00000598840	ENSP00000470741
ENST00000596995	ENSP00000473037
ENST00000600753	ENSP00000469978
ENST00000594526	ENSP00000472389
ENST00000594144	ENSP00000471010
ENST00000597808	ENSP00000469938
ENST00000600706	ENSP00000468931

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	56 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004839	ubiquitin activating enzyme activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008047	enzyme activator activity
GO:0008641	small protein activating enzyme activity
GO:0019948	SUMO activating enzyme activity
GO:0043008	ATP-dependent protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006464	cellular protein modification process
GO:0007346	regulation of mitotic cell cycle
GO:0008152	metabolic process
GO:0016567	protein ubiquitination
GO:0016925	protein sumoylation
GO:0019950	SMT3-dependent protein catabolic process
GO:0043085	positive regulation of catalytic activity
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000052833

View Gene Order

ENSBTAG00000002676

Not yet available

Pathways

NETPATH

REACTOME

REACT_22161

Post-translational protein modification pathway

REACT_163793

Processing and activation of SUMO pathway

REACT_17015

Metabolism of proteins pathway

REACT_163646

SUMO is transferred from E1 to E2 (UBE2I, UBC9) pathway

REACT_163812

SUMO is conjugated to E1 (UBA2:SAE1) pathway

REACT_163823

SUMOylation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.620309

RefSeq

NM_001145713 NM_001145714 NM_005500 XM_006722964

HUGO

OMIM

CCDS

CCDS12696 CCDS54284 CCDS54285

HPRD

18010

IMGT

EMBL

GenPept

RNA Seq Atlas