Homo sapiens Protein: CMKLR1 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Protein | IDBP-592942.3 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | CMKLR1 | ||||||||||||||||||||
Protein Name | chemokine-like receptor 1 | ||||||||||||||||||||
Synonyms | CHEMERINR; ChemR23; DEZ; RVER1; | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Protein | ENSP00000449716 | ||||||||||||||||||||
InnateDB Gene | IDBG-55274 (CMKLR1) | ||||||||||||||||||||
Protein Structure | |||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||
Function | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). {ECO:0000269PubMed:15728234, ECO:0000269PubMed:15753205, ECO:0000269PubMed:20044979, ECO:0000269PubMed:9603476}. | ||||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000269PubMed:15728234, ECO:0000269PubMed:16863918}; Multi-pass membrane protein {ECO:0000269PubMed:15728234, ECO:0000269PubMed:16863918}. | ||||||||||||||||||||
Disease Associations | |||||||||||||||||||||
Tissue Specificity | Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes. {ECO:0000269PubMed:14530373, ECO:0000269PubMed:15728234, ECO:0000269PubMed:15753205, ECO:0000269PubMed:18242188, ECO:0000269PubMed:20044979, ECO:0000269PubMed:8976386}. | ||||||||||||||||||||
Comments | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||
PDB ID | |||||||||||||||||||||
InterPro |
IPR000248
Angiotensin II receptor family IPR000276 G protein-coupled receptor, rhodopsin-like IPR002234 Anaphylatoxin chemotactic receptor family IPR002258 DEZ orphan receptor IPR017452 GPCR, rhodopsin-like, 7TM |
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PFAM |
PF00001
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PRINTS |
PR00241
PR00237 PR01104 PR01126 |
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PIRSF | |||||||||||||||||||||
SMART | |||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||
Modification | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | Q99788 | ||||||||||||||||||||
PhosphoSite | PhosphoSite-Q99788 | ||||||||||||||||||||
TrEMBL | F8VYN7 | ||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 1240 | ||||||||||||||||||||
UniGene | Hs.197143 | ||||||||||||||||||||
RefSeq | NP_001135815 | ||||||||||||||||||||
HUGO | HGNC:2121 | ||||||||||||||||||||
OMIM | 602351 | ||||||||||||||||||||
CCDS | CCDS44965 | ||||||||||||||||||||
HPRD | 03829 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AB065871 AC009729 AC063957 AK291800 AY497547 BC106927 BC106928 BT019556 BT019557 CH471054 U79526 U79527 Y14838 | ||||||||||||||||||||
GenPept | AAC51258 AAC51259 AAI06928 AAI06929 AAR90850 AAV38363 AAV38364 BAC06089 BAF84489 CAA75112 EAW97810 EAW97811 | ||||||||||||||||||||