InnateDB Protein
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IDBP-593152.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SMC2
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Protein Name
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structural maintenance of chromosomes 2
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Synonyms
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CAP-E; CAPE; SMC-2; SMC2L1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000431534
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InnateDB Gene
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IDBG-79195 (SMC2)
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Protein Structure
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Function |
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269PubMed:11136719}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:10958694}. Cytoplasm {ECO:0000269PubMed:10958694}. Chromosome {ECO:0000269PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
54
[view]
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Protein-Protein |
51
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95347
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PhosphoSite |
PhosphoSite-O95347
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10592
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UniGene |
Hs.119023
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RefSeq |
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HUGO |
HGNC:14011
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OMIM |
605576
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CCDS |
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HPRD |
09277
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IMGT |
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EMBL |
AF092563
AF113673
AL161791
AL354938
AL833191
BC130385
BN000163
CH471105
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GenPept |
AAC72360
AAF29579
AAI30386
CAD89875
CAI16866
CAI16923
CAI46187
EAW58973
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