Homo sapiens Gene: SMC2
Summary
InnateDB Gene IDBG-79195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMC2
Gene Name structural maintenance of chromosomes 2
Synonyms CAP-E; CAPE; SMC-2; SMC2L1;
Species Homo sapiens
Ensembl Gene ENSG00000136824
Encoded Proteins
structural maintenance of chromosomes 2
structural maintenance of chromosomes 2
structural maintenance of chromosomes 2
structural maintenance of chromosomes 2
structural maintenance of chromosomes 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:104094260-104141417
Strand Forward strand
Band q31.1
Transcripts
ENST00000286398 ENSP00000286398
ENST00000374793 ENSP00000363925
ENST00000374787 ENSP00000363919
ENST00000440179 ENSP00000414999
ENST00000493955 ENSP00000431534
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 51 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0007076 mitotic chromosome condensation
GO:0010032 meiotic chromosome condensation
GO:0045132 meiotic chromosome segregation
GO:0051276 chromosome organization
GO:0051383 kinetochore organization
Cellular Component
GO:0000228 nuclear chromosome
GO:0000793 condensed chromosome
GO:0000796 condensin complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Condensation of Prophase Chromosomes pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Condensation of Prometaphase Chromosomes pathway
M Phase pathway
Mitotic Prophase pathway
Cell Cycle, Mitotic pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Aurora B signaling
Cross-References
SwissProt O95347
TrEMBL A0A024R158 Q5T821
UniProt Splice Variant
Entrez Gene 10592
UniGene Hs.119023
RefSeq NM_001042551 NM_001265602 NM_006444 NM_001042550 XM_006716933
HUGO HGNC:14011
OMIM 605576
CCDS CCDS35086
HPRD 09277
IMGT
EMBL AF092563 AF113673 AL161791 AL354938 AL833191 BC130385 BN000163 CH471105
GenPept AAC72360 AAF29579 AAI30386 CAD89875 CAI16866 CAI16923 CAI46187 EAW58973 EAW58975 EAW58977
RNA Seq Atlas 10592