InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VAV3

Summary

InnateDB Protein

IDBP-593163.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAV3

Protein Name

vav 3 guanine nucleotide exchange factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000433559

InnateDB Gene

IDBG-100649 (VAV3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR003096 Smooth muscle protein/calponin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM

PF00621
PF00307
PF00169
PF00130
PF11971

PRINTS

PR00888

PIRSF

SMART

SM00325
SM00033
SM00233
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt