InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNX1

Summary

InnateDB Protein

IDBP-593381.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX1

Protein Name

sorting nexin 1

Synonyms

HsT17379; VPS5;

Species

Homo sapiens

Ensembl Protein

ENSP00000453785

InnateDB Gene

IDBG-16207 (SNX1)

Protein Structure

UniProt Annotation

Function

May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000269PubMed:12198132, ECO:0000269PubMed:15498486, ECO:0000269PubMed:17101778}.

Subcellular Localization

Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.

Experimentally validated
Total	58 [view]
Protein-Protein	55 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0034498	early endosome to Golgi transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0010008	endosome membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030904	retromer complex
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle