InnateDB Protein
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IDBP-593786.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TPT1
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Protein Name
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tumor protein, translationally-controlled 1
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Synonyms
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HRF; p02; p23; TCTP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000431872
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InnateDB Gene
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IDBG-29334 (TPT1)
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Protein Structure
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Function |
Involved in calcium binding and microtubule stabilization.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:9059837}.
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Disease Associations |
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Tissue Specificity |
Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate. {ECO:0000269PubMed:9059837}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
51
[view]
|
Protein-Protein |
48
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011057
Mss4-like
IPR018105
Translationally controlled tumour protein
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PFAM |
PF00838
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PRINTS |
PR01653
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P13693
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PhosphoSite |
PhosphoSite-P13693
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TrEMBL |
Q86YH5
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UniProt Splice Variant |
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Entrez Gene |
7178
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UniGene |
Hs.728858
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RefSeq |
NP_003286
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HUGO |
HGNC:12022
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OMIM |
600763
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CCDS |
CCDS9397
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HPRD |
15979
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IMGT |
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EMBL |
AJ400717
AK312951
AL138963
AY117678
AY334563
BC003352
BC012431
BC022436
BC040008
BC052333
CH471075
CR457036
X16064
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GenPept |
AAH03352
AAH12431
AAH22436
AAH40008
AAH52333
AAM51565
AAQ01550
BAG35792
CAA34200
CAB87812
CAG33317
CAH72034
EAX08731
EAX08732
EAX08735
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