InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP39

Summary

InnateDB Protein

IDBP-59381.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP39

Protein Name

ubiquitin specific peptidase 39

Synonyms

65K; HSPC332; SAD1; SNRNP65;

Species

Homo sapiens

Ensembl Protein

ENSP00000312981

InnateDB Gene

IDBG-59379 (USP39)

Protein Structure

UniProt Annotation

Function

Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs). {ECO:0000269PubMed:11350945, ECO:0000269PubMed:18728397}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11350945}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.

Experimentally validated
Total	82 [view]
Protein-Protein	81 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0000245	spliceosomal complex assembly
GO:0006397	mRNA processing
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0008380	RNA splicing
GO:0051301	cell division

Cellular Component

GO:0005681

spliceosomal complex

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR001607 Zinc finger, UBP-type
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF02148

PRINTS

PIRSF

SMART

SM00290

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q53GS9