InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TXN2

Summary

InnateDB Protein

IDBP-5940.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TXN2

Protein Name

thioredoxin 2

Synonyms

MT-TRX; MTRX; TRX2;

Species

Homo sapiens

Ensembl Protein

ENSP00000216185

InnateDB Gene

IDBG-5938 (TXN2)

Protein Structure

UniProt Annotation

Function

Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. {ECO:0000269PubMed:12032145, ECO:0000269PubMed:12080052}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:12032145, ECO:0000269PubMed:12080052}.

Disease Associations

Tissue Specificity

Widely expressed in adult (at protein level) and fetal tissues. {ECO:0000269PubMed:12032145, ECO:0000269PubMed:12080052}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008113	peptide-methionine (S)-S-oxide reductase activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0032403	protein complex binding
GO:0033743	peptide-methionine (R)-S-oxide reductase activity

Biological Process

GO:0001666	response to hypoxia
GO:0006662	glycerol ether metabolic process
GO:0006979	response to oxidative stress
GO:0007584	response to nutrient
GO:0009725	response to hormone
GO:0009749	response to glucose
GO:0014070	response to organic cyclic compound
GO:0031669	cellular response to nutrient levels
GO:0042493	response to drug
GO:0045454	cell redox homeostasis
GO:0048678	response to axon injury
GO:0055114	oxidation-reduction process