Version 5.4
Homo sapiens Protein: SPAG9
Summary
InnateDB Protein IDBP-59413.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAG9
Protein Name sperm associated antigen 9
Synonyms CT89; HLC-6; HLC4; JIP-4; JIP4; JLP; PHET; PIG6;
Species Homo sapiens
Ensembl Protein ENSP00000349636
InnateDB Gene IDBG-59405 (SPAG9)
Protein Structure
UniProt Annotation
Function The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction. {ECO:0000269PubMed:14743216, ECO:0000269PubMed:15693750}.
Subcellular Localization Cytoplasm. Cytoplasm, perinuclear region. Note=Perinuclear distribution in response to stress signals such as UV radiation.Isoform 5: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.
Disease Associations
Tissue Specificity Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. {ECO:0000269PubMed:14662895, ECO:0000269PubMed:16112646, ECO:0000269PubMed:9480848}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007283 spermatogenesis
GO:0030335 positive regulation of cell migration
GO:0042147 retrograde transport, endosome to Golgi
GO:0042692 muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR017986 WD40-repeat-containing domain
IPR019143 JNK/Rab-associated protein-1, N-terminal
PFAM PF09744
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60271
PhosphoSite PhosphoSite-O60271
TrEMBL H0Y981
UniProt Splice Variant
Entrez Gene 9043
UniGene Hs.738131
RefSeq NP_003962
HUGO HGNC:14524
OMIM 605430
CCDS CCDS11577
HPRD 10398
IMGT
EMBL AB011088 AC005839 AC005920 AF327452 AK024068 AK295098 AK302789 AY219897 AY219898 AY850123 BC007524 BC059946 BC106048 BC146755 BC153878 X91879
GenPept AAH07524 AAH59946 AAI06049 AAI46756 AAI53879 AAN61565 AAO66462 AAO66463 AAX47276 BAA25442 BAB14812 BAG58134 BAG63993 CAA62987

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca