InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNASEL

Summary

InnateDB Protein

IDBP-594521.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNASEL

Protein Name

ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

Synonyms

PRCA1; RNS4;

Species

Homo sapiens

Ensembl Protein

ENSP00000440844

InnateDB Gene

IDBG-105248 (RNASEL)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004540	ribonuclease activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0090501	RNA phosphodiester bond hydrolysis

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR010513 KEN domain
IPR011009 Protein kinase-like domain
IPR020683 Ankyrin repeat-containing domain

PFAM