Version 5.4
Homo sapiens Protein: CS
Summary
InnateDB Protein IDBP-594691.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CS
Protein Name citrate synthase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000446779
InnateDB Gene IDBG-40658 (CS)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Mitochondrion matrix.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004108 citrate (Si)-synthase activity
GO:0044822 poly(A) RNA binding
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0044237 cellular metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002020 Citrate synthase-like
IPR010109 Citrate synthase, eukaryotic
IPR016141 Citrate synthase-like, core
PFAM PF00285
PRINTS PR00143
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75390
PhosphoSite PhosphoSite-O75390
TrEMBL Q0QEL2
UniProt Splice Variant
Entrez Gene 1431
UniGene Hs.743252
RefSeq
HUGO HGNC:2422
OMIM 118950
CCDS
HPRD 00349
IMGT
EMBL AC073896 AF047042 AF053631 AK074956 BC000105 BC010106 BC072016 BT007414 BX640838 DQ403132
GenPept AAC25560 AAH00105 AAH10106 AAH72016 AAP36082 AAQ13428 ABD77265 BAC11314 CAE45911

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca