Version 5.4
Homo sapiens Gene: CS
Summary
InnateDB Gene IDBG-40658.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CS
Gene Name citrate synthase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000062485
Encoded Proteins
IDBP-40660
citrate synthase
IDBP-583552
citrate synthase
IDBP-594691
citrate synthase
IDBP-585649
citrate synthase
IDBP-591659
citrate synthase
IDBP-594248
citrate synthase
IDBP-592744
citrate synthase
IDBP-590524
citrate synthase
IDBP-586246
citrate synthase
IDBP-589608
citrate synthase
IDBP-590761
citrate synthase
IDBP-585214
citrate synthase
IDBP-592329
citrate synthase
IDBP-601040
citrate synthase
IDBP-583724
citrate synthase
IDBP-596914
citrate synthase
IDBP-596907
citrate synthase
IDBP-586683
citrate synthase
IDBP-593900
citrate synthase
IDBP-592839
citrate synthase
IDBP-593497
citrate synthase
IDBP-596644
citrate synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56271699-56300392
Strand Reverse strand
Band q13.3
Transcripts
ENST00000351328 ENSP00000342056
ENST00000549143 ENSP00000449571
ENST00000548567 ENSP00000446779
ENST00000548746 ENSP00000449080
ENST00000542324 ENSP00000440543
ENST00000546621
ENST00000546891 ENSP00000446492
ENST00000546585
ENST00000548849 ENSP00000449491
ENST00000552331
ENST00000549221 ENSP00000448667
ENST00000546930 ENSP00000450403
ENST00000548041 ENSP00000447986
ENST00000551936 ENSP00000450312
ENST00000550734 ENSP00000449025
ENST00000551253 ENSP00000450101
ENST00000547449
ENST00000547912
ENST00000552688 ENSP00000447442
ENST00000551473 ENSP00000449427
ENST00000547298 ENSP00000448409
ENST00000551137 ENSP00000449753
ENST00000550655 ENSP00000448172
ENST00000551968 ENSP00000447948
ENST00000550159 ENSP00000447346
ENST00000551430 ENSP00000448166
ENST00000552222 ENSP00000447582
ENST00000547283
ENST00000550996
ENST00000551155
ENST00000550700
ENST00000551441
ENST00000550044
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004108 citrate (Si)-synthase activity
GO:0044822 poly(A) RNA binding
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0044237 cellular metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005683
View Gene Order
ENSBTAG00000004371
Not yet available
Pathways
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_17015
Metabolism of proteins pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.735445 Hs.743252
RefSeq NM_004077
HUGO
OMIM
CCDS CCDS8913
HPRD 00349
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca