InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: THY1

Summary

InnateDB Protein

IDBP-594982.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THY1

Protein Name

Thy-1 cell surface antigen

Synonyms

CD90;

Species

Homo sapiens

Ensembl Protein

ENSP00000431301

InnateDB Gene

IDBG-74502 (THY1)

Protein Structure

UniProt Annotation

Function

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0034235	GPI anchor binding

Biological Process

GO:0001525	angiogenesis
GO:0006469	negative regulation of protein kinase activity
GO:0007010	cytoskeleton organization
GO:0016337	single organismal cell-cell adhesion
GO:0030336	negative regulation of cell migration
GO:0043547	positive regulation of GTPase activity
GO:0046549	retinal cone cell development
GO:0048041	focal adhesion assembly
GO:0050771	negative regulation of axonogenesis
GO:0050852	T cell receptor signaling pathway
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016324	apical plasma membrane
GO:0030426	growth cone
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome