InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FZD3

Summary

InnateDB Protein

IDBP-595713.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD3

Protein Name

frizzled family receptor 3

Synonyms

Fz-3;

Species

Homo sapiens

Ensembl Protein

ENSP00000437489

InnateDB Gene

IDBG-15189 (FZD3)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001736	establishment of planar polarity
GO:0001764	neuron migration
GO:0001843	neural tube closure
GO:0001942	hair follicle development
GO:0001944	vasculature development
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0008406	gonad development
GO:0021754	facial nucleus development
GO:0030182	neuron differentiation
GO:0030901	midbrain development
GO:0033278	cell proliferation in midbrain
GO:0036342	post-anal tail morphogenesis
GO:0042472	inner ear morphogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0071679	commissural neuron axon guidance

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0032589	neuron projection membrane
GO:0043025	neuronal cell body
GO:0045177	apical part of cell
GO:0048786	presynaptic active zone