Homo sapiens Gene: FZD3
Summary
InnateDB Gene IDBG-15189.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FZD3
Gene Name frizzled family receptor 3
Synonyms Fz-3;
Species Homo sapiens
Ensembl Gene ENSG00000104290
Encoded Proteins
frizzled family receptor 3
frizzled family receptor 3
frizzled family receptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:28494205-28574268
Strand Forward strand
Band p21.1
Transcripts
ENST00000240093 ENSP00000240093
ENST00000523546 ENSP00000430125
ENST00000517911
ENST00000537916 ENSP00000437489
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0001736 establishment of planar polarity
GO:0001764 neuron migration
GO:0001843 neural tube closure
GO:0001942 hair follicle development
GO:0001944 vasculature development
GO:0007166 cell surface receptor signaling pathway
GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0008406 gonad development
GO:0021754 facial nucleus development
GO:0030182 neuron differentiation
GO:0030901 midbrain development
GO:0033278 cell proliferation in midbrain
GO:0036342 post-anal tail morphogenesis
GO:0042472 inner ear morphogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0071679 commissural neuron axon guidance
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0032589 neuron projection membrane
GO:0043025 neuronal cell body
GO:0045177 apical part of cell
GO:0048786 presynaptic active zone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Wnt pathway
REACTOME
PCP/CE pathway pathway
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
Signal Transduction pathway
Asymmetric localization of PCP proteins pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
KEGG
Wnt signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.312497 Hs.40735 Hs.596498 Hs.714614 Hs.734277
RefSeq NM_017412 NM_145866
HUGO
OMIM
CCDS CCDS6069
HPRD 05849
IMGT
EMBL
GenPept
RNA Seq Atlas