InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FZD3

Summary

InnateDB Gene

IDBG-15189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD3

Gene Name

frizzled family receptor 3

Synonyms

Fz-3

Species

Homo sapiens

Ensembl Gene

ENSG00000104290

Encoded Proteins

IDBP-15193

frizzled family receptor 3

IDBP-478146

frizzled family receptor 3

IDBP-595713

frizzled family receptor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:28494205-28574268

Strand

Forward strand

Band

p21.1

Transcripts

ENST00000240093	ENSP00000240093
ENST00000523546	ENSP00000430125
ENST00000517911
ENST00000537916	ENSP00000437489

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001736	establishment of planar polarity
GO:0001764	neuron migration
GO:0001843	neural tube closure
GO:0001942	hair follicle development
GO:0001944	vasculature development
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0008406	gonad development
GO:0021754	facial nucleus development
GO:0030182	neuron differentiation
GO:0030901	midbrain development
GO:0033278	cell proliferation in midbrain
GO:0036342	post-anal tail morphogenesis
GO:0042472	inner ear morphogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0071679	commissural neuron axon guidance

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0032589	neuron projection membrane
GO:0043025	neuronal cell body
GO:0045177	apical part of cell
GO:0048786	presynaptic active zone