|
InnateDB Protein
|
IDBP-596241.3
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
POU2F1
|
|
Protein Name
|
POU class 2 homeobox 1
|
|
Synonyms
|
oct-1B; OCT1; OTF1;
|
|
Species
|
Homo sapiens
|
|
Ensembl Protein
|
ENSP00000453094
|
|
InnateDB Gene
|
IDBG-104534 (POU2F1)
|
|
Protein Structure
|
|
| Function |
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000250, ECO:0000269PubMed:1684878}.
|
| Subcellular Localization |
Nucleus.
|
| Disease Associations |
|
| Tissue Specificity |
Ubiquitous. Isoform 2 is lymphocyte-specific.
|
| Comments |
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
97
[view]
|
| Protein-Protein |
81
[view]
|
| Protein-DNA |
16
[view]
|
| Protein-RNA |
0
|
| DNA-DNA |
0
|
| RNA-RNA |
0
|
| DNA-RNA |
0
|
|
| Predicted by orthology |
| Total |
13 [view]
|
|
|
| PDB ID |
|
| InterPro |
|
| PFAM |
|
| PRINTS |
|
| PIRSF |
|
| SMART |
|
| TIGRFAMs |
|
| Modification |
|
| SwissProt |
|
| PhosphoSite |
PhosphoSite-P14859
|
| TrEMBL |
Q16075
|
| UniProt Splice Variant |
|
| Entrez Gene |
5451
|
| UniGene |
Hs.617075
|
| RefSeq |
|
| HUGO |
HGNC:9212
|
| OMIM |
164175
|
| CCDS |
|
| HPRD |
01250
|
| IMGT |
|
| EMBL |
S66901
|
| GenPept |
AAB28879
|
|
|
|
Version 5.4