InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBM10

Summary

InnateDB Protein

IDBP-59676.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBM10

Protein Name

RNA binding motif protein 10

Synonyms

DXS8237E; GPATC9; GPATCH9; S1-1; TARPS; ZRANB5;

Species

Homo sapiens

Ensembl Protein

ENSP00000366829

InnateDB Gene

IDBG-59674 (RBM10)

Protein Structure

UniProt Annotation

Function

May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18315527}. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).

Disease Associations

TARP syndrome (TARPS) [MIM:311900]: A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects. {ECO:0000269PubMed:20451169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	80 [view]
Protein-Protein	80 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding