Version 5.4
Homo sapiens Protein: SLC43A1
Summary
InnateDB Protein IDBP-596776.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC43A1
Protein Name solute carrier family 43, member 1
Synonyms LAT3; PB39; POV1; R00504;
Species Homo sapiens
Ensembl Protein ENSP00000435673
InnateDB Gene IDBG-46661 (SLC43A1)
Protein Structure
UniProt Annotation
Function Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. {ECO:0000269PubMed:11956097, ECO:0000269PubMed:12930836, ECO:0000269PubMed:9255310, ECO:0000269PubMed:9722952}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells. {ECO:0000269PubMed:11956097, ECO:0000269PubMed:12930836, ECO:0000269PubMed:9255310, ECO:0000269PubMed:9722952}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015175 neutral amino acid transmembrane transporter activity
Biological Process
GO:0006811 ion transport
GO:0006865 amino acid transport
GO:0015804 neutral amino acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
PFAM PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75387
PhosphoSite PhosphoSite-O75387
TrEMBL E9PJT8
UniProt Splice Variant
Entrez Gene 8501
UniGene Hs.735724
RefSeq NP_001185739
HUGO HGNC:9225
OMIM 603733
CCDS CCDS7958
HPRD 07227
IMGT
EMBL AB103033 AF045584 AK027732 AP002893 BC001639 CH471076
GenPept AAC33004 AAH01639 BAD00152 BAG51373 EAW73750 EAW73751

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca