InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAOK1

Summary

InnateDB Protein

IDBP-596959.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAOK1

Protein Name

TAO kinase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000438819

InnateDB Gene

IDBG-38294 (TAOK1)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. {ECO:0000269PubMed:12665513, ECO:0000269PubMed:13679851, ECO:0000269PubMed:16407310, ECO:0000269PubMed:17396146, ECO:0000269PubMed:17900936}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:13679851}.

Disease Associations

Tissue Specificity

Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle. {ECO:0000269PubMed:13679851, ECO:0000269PubMed:9786855}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0000278	mitotic cell cycle
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0031572	G2 DNA damage checkpoint
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0046330	positive regulation of JNK cascade
GO:0051493	regulation of cytoskeleton organization
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR009057 Homeodomain-like
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt