InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CACNB2

Summary

InnateDB Protein

IDBP-59698.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNB2

Protein Name

calcium channel, voltage-dependent, beta 2 subunit

Synonyms

CACNLB2; CAVB2; MYSB;

Species

Homo sapiens

Ensembl Protein

ENSP00000366546

InnateDB Gene

IDBG-59692 (CACNB2)

Protein Structure

UniProt Annotation

Function

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Subcellular Localization

Cell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Brugada syndrome 4 (BRGDA4) [MIM:611876]: A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO:0000269PubMed:17224476}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in all tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005245	voltage-gated calcium channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity

Biological Process

GO:0006810	transport
GO:0007411	axon guidance
GO:0007528	neuromuscular junction development
GO:0034765	regulation of ion transmembrane transport
GO:0051928	positive regulation of calcium ion transport
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0042383	sarcolemma

Protein Structure and Domains

PDB ID

InterPro

IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
IPR001452 SH3 domain
IPR005444 Voltage-dependent calcium channel, L-type, beta-2 subunit
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF12052
PF00018
PF14604
PF00625

PRINTS

PR01626
PR00452
PR01628

PIRSF

SMART

SM00326
SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt