Homo sapiens Gene: CACNB2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-59692.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CACNB2 | ||||||||||||||||||||||
Gene Name | calcium channel, voltage-dependent, beta 2 subunit | ||||||||||||||||||||||
Synonyms | CACNLB2; CAVB2; MYSB | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000165995 | ||||||||||||||||||||||
Encoded Proteins |
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
calcium channel, voltage-dependent, beta 2 subunit
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 10:18140677-18541869 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | p12.33 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Adrenaline,noradrenaline inhibits insulin secretion pathway
Regulation of insulin secretion pathway
Integration of energy metabolism pathway
NCAM1 interactions pathway
NCAM signaling for neurite out-growth pathway
Developmental Biology pathway
Neuronal System pathway
Axon guidance pathway
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
Transmission across Chemical Synapses pathway
Metabolism pathway
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KEGG |
MAPK signaling pathway pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Hypertrophic cardiomyopathy (HCM) pathway
Cardiac muscle contraction pathway
Dilated cardiomyopathy pathway
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INOH |
GPCR Dopamine D1like receptor signaling pathway pathway
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PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.59093 | ||||||||||||||||||||||
RefSeq | NM_000724 NM_001167945 NM_201570 NM_201571 NM_201572 NM_201590 NM_201593 NM_201596 NM_201597 XM_005252588 XM_005252591 XM_006717502 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS41493 CCDS41494 CCDS7125 CCDS7126 CCDS7127 CCDS7128 CCDS7129 | ||||||||||||||||||||||
HPRD | 02473 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||