InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EHD2

Summary

InnateDB Protein

IDBP-59726.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EHD2

Protein Name

EH-domain containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263277

InnateDB Gene

IDBG-59724 (EHD2)

Protein Structure

UniProt Annotation

Function

Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Required for translocation of FER1L5 to the plasma membrane. Binds ATP; does not bind GTP (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17233914}; Peripheral membrane protein {ECO:0000269PubMed:17233914}; Cytoplasmic side {ECO:0000269PubMed:17233914}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003924	GTPase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006897	endocytosis
GO:0007596	blood coagulation
GO:0030866	cortical actin cytoskeleton organization
GO:0032456	endocytic recycling
GO:0072659	protein localization to plasma membrane
GO:1901741	positive regulation of myoblast fusion
GO:2001137	positive regulation of endocytic recycling

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome