Version 5.4
Homo sapiens Protein: PRG2
Summary
InnateDB Protein IDBP-597587.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRG2
Protein Name proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Synonyms BMPG; MBP; MBP1;
Species Homo sapiens
Ensembl Protein ENSP00000433016
InnateDB Gene IDBG-46552 (PRG2)
Protein Structure
UniProt Annotation
Function Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. {ECO:0000269PubMed:10913121}.
Subcellular Localization Bone marrow proteoglycan: Secreted. Note=The proform is secreted.Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
Disease Associations
Tissue Specificity High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. {ECO:0000269PubMed:10491647, ECO:0000269PubMed:7526035}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 7 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008201 heparin binding
GO:0030246 carbohydrate binding
Biological Process
GO:0006955 immune response
GO:0042742 defense response to bacterium
Cellular Component
GO:0005576 extracellular region
GO:0030133 transport vesicle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR002352 Eosinophil major basic protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00770
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P13727
PhosphoSite PhosphoSite-P13727
TrEMBL
UniProt Splice Variant
Entrez Gene 5553
UniGene
RefSeq
HUGO HGNC:9362
OMIM 605601
CCDS CCDS7955
HPRD 09283
IMGT
EMBL AP000781 BC005929 CR450311 M34462 M35670 M36805 X14088 X65787 Y00809 Z26248
GenPept AAA35796 AAA35965 AAA36203 AAH05929 CAA32250 CAA46670 CAA68751 CAA81207 CAG29307

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca