Homo sapiens Gene: PRG2
Summary
InnateDB Gene IDBG-46552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRG2
Gene Name proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Synonyms BMPG; MBP; MBP1;
Species Homo sapiens
Ensembl Gene ENSG00000186652
Encoded Proteins
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:57386794-57390657
Strand Reverse strand
Band q12.1
Transcripts
ENST00000311862 ENSP00000312134
ENST00000533605 ENSP00000433231
ENST00000525955 ENSP00000433016
ENST00000530105
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 7 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008201 heparin binding
GO:0030246 carbohydrate binding
Biological Process
GO:0002215 defense response to nematode
GO:0006955 immune response
GO:0032693 negative regulation of interleukin-10 production
GO:0032753 positive regulation of interleukin-4 production
GO:0042742 defense response to bacterium
Cellular Component
GO:0005576 extracellular region
GO:0030133 transport vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Asthma pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P13727
TrEMBL
UniProt Splice Variant
Entrez Gene 5553
UniGene
RefSeq NM_002728 NM_001243245
HUGO HGNC:9362
OMIM 605601
CCDS CCDS7955 CCDS58133
HPRD 09283
IMGT
EMBL AP000781 BC005929 CR450311 M34462 M35670 M36805 X14088 X65787 Y00809 Z26248
GenPept AAA35796 AAA35965 AAA36203 AAH05929 CAA32250 CAA46670 CAA68751 CAA81207 CAG29307
RNA Seq Atlas 5553