InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ORC4

Summary

InnateDB Protein

IDBP-597844.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ORC4

Protein Name

origin recognition complex, subunit 4

Synonyms

ORC4L; ORC4P;

Species

Homo sapiens

Ensembl Protein

ENSP00000441502

InnateDB Gene

IDBG-71780 (ORC4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	37 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003688	DNA replication origin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006270	DNA replication initiation

Cellular Component

GO:0000808	origin recognition complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005664	nuclear origin of replication recognition complex

Protein Structure and Domains

PDB ID

InterPro

IPR003959 ATPase, AAA-type, core
IPR016527 Origin recognition complex, subunit 4
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304

PRINTS

PIRSF

PIRSF007858

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43929

PhosphoSite

PhosphoSite-O43929

TrEMBL

Q53TH5

UniProt Splice Variant

Entrez Gene

5000

UniGene

Hs.558364

RefSeq

NP_001177810

HUGO

HGNC:8490

OMIM

603056

CCDS

CCDS54404

HPRD

09118

IMGT

EMBL

AC009480 AC019226 AF022108 AF047598 AF132596 AK295721 AK298862 AK299749 AY600302 BC014847 CH471058

GenPept

AAC01957 AAC80282 AAD22110 AAH14847 AAS94326 AAX93051 BAH12166 BAH12887 BAH13118 EAX11555 EAX11556 EAX11557 EAX11558 EAX11560