InnateDB Protein
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IDBP-59786.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRELID1
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Protein Name
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PRELI domain containing 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000302114
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InnateDB Gene
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IDBG-59784 (PRELID1)
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Protein Structure
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Function |
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs. {ECO:0000269PubMed:18945965, ECO:0000269PubMed:21364629, ECO:0000269PubMed:23931759}.
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Subcellular Localization |
Mitochondrion. Mitochondrion intermembrane space.
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Disease Associations |
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Tissue Specificity |
Highly expressed in fetal liver; less expressed in fetal brain, lung, and kidney. At the adult stage, expression is drastically reduced in the liver but highly expressed in the spleen, brain, lung, lymph nodes and peripheral blood leukocytes.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0006955
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immune response
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GO:0007275
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multicellular organismal development
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GO:0010917
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negative regulation of mitochondrial membrane potential
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GO:0010950
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positive regulation of endopeptidase activity
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GO:0015914
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phospholipid transport
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GO:0043066
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negative regulation of apoptotic process
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GO:0045580
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regulation of T cell differentiation
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GO:0051881
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regulation of mitochondrial membrane potential
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GO:0070234
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positive regulation of T cell apoptotic process
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GO:0090201
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negative regulation of release of cytochrome c from mitochondria
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GO:0097035
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regulation of membrane lipid distribution
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GO:1901857
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positive regulation of cellular respiration
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GO:1902511
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negative regulation of apoptotic DNA fragmentation
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GO:2001140
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positive regulation of phospholipid transport
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Cellular Component |
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PDB ID |
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InterPro |
IPR006797
PRELI/MSF1
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PFAM |
PF04707
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y255
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PhosphoSite |
PhosphoSite-Q9Y255
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
27166
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UniGene |
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RefSeq |
NP_037369
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HUGO |
HGNC:30255
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OMIM |
605733
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CCDS |
CCDS4415
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HPRD |
16149
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IMGT |
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EMBL |
AC146507
AF087858
AF111112
AF112203
AF151864
AF153607
AF201925
AK312170
BC000007
BC007268
BC008307
BC008866
BC013733
BC013748
BC078182
CH471195
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GenPept |
AAD34101
AAD41089
AAF09255
AAF17191
AAF27195
AAH00007
AAH07268
AAH08307
AAH08866
AAH13733
AAH13748
AAH78182
AAP97168
BAG35104
EAW85022
EAW85023
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