InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VDAC2

Summary

InnateDB Protein

IDBP-598005.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VDAC2

Protein Name

voltage-dependent anion channel 2

Synonyms

POR;

Species

Homo sapiens

Ensembl Protein

ENSP00000443092

InnateDB Gene

IDBG-79237 (VDAC2)

Protein Structure

UniProt Annotation

Function

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000269PubMed:7539795}.

Disease Associations

Tissue Specificity

Expressed in all tissues examined.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	57 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0008308	voltage-gated anion channel activity
GO:0015288	porin activity

Biological Process

GO:0006820	anion transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0042645	mitochondrial nucleoid
GO:0046930	pore complex
GO:0070062	extracellular vesicular exosome