InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS29

Summary

InnateDB Protein

IDBP-598008.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS29

Protein Name

vacuolar protein sorting 29 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000447058

InnateDB Gene

IDBG-57168 (VPS29)

Protein Structure

UniProt Annotation

Function

Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro). {ECO:0000269PubMed:15247922}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.

Experimentally validated
Total	57 [view]
Protein-Protein	51 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004647	phosphoserine phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0015031	protein transport
GO:0016311	dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome