Homo sapiens Gene: VPS29
Summary
InnateDB Gene IDBG-57168.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS29
Gene Name vacuolar protein sorting 29 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111237
Encoded Proteins
vacuolar protein sorting 29 homolog (S. cerevisiae)
vacuolar protein sorting 29 homolog (S. cerevisiae)
vacuolar protein sorting 29 homolog (S. cerevisiae)
vacuolar protein sorting 29 homolog (S. cerevisiae)
vacuolar protein sorting 29 homolog (S. cerevisiae)
vacuolar protein sorting 29 homolog (S. cerevisiae)
vacuolar protein sorting 29 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:110491097-110502117
Strand Reverse strand
Band q24.11
Transcripts
ENST00000360579 ENSP00000353786
ENST00000447578 ENSP00000400048
ENST00000549578 ENSP00000447058
ENST00000552130 ENSP00000449954
ENST00000546588 ENSP00000449044
ENST00000548539
ENST00000549970 ENSP00000447634
ENST00000548259
ENST00000553128
ENST00000551655
ENST00000550267
ENST00000621131 ENSP00000480853
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
Experimentally validated
Total 57 [view]
Protein-Protein 51 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004647 phosphoserine phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0015031 protein transport
GO:0016311 dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
Signal Transduction pathway
WNT ligand biogenesis and trafficking pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UBQ0
TrEMBL E9RKB4 Q05DG7
UniProt Splice Variant
Entrez Gene 51699
UniGene Hs.600114
RefSeq NM_016226 XM_006719459 NM_057180 NM_001282150 XM_006719462
HUGO HGNC:14340
OMIM 606932
CCDS CCDS41832 CCDS53832 CCDS73525
HPRD 09499
IMGT
EMBL AB618733 AC002350 AF168716 AF175264 AF193795 AF201936 AF201946 AL136614 BC000880 BC015095 BC095446 CR457182 CR533468
GenPept AAF04596 AAF17238 AAF86872 AAF87318 AAF89952 AAH00880 AAH15095 AAH95446 BAJ83889 CAB66549 CAG33463 CAG38499
RNA Seq Atlas 51699