InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LMAN2

Summary

InnateDB Protein

IDBP-59806.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMAN2

Protein Name

lectin, mannose-binding 2

Synonyms

C5orf8; GP36B; VIP36;

Species

Homo sapiens

Ensembl Protein

ENSP00000303366

InnateDB Gene

IDBG-59804 (LMAN2)

Protein Structure

UniProt Annotation

Function

Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269PubMed:10444376}. Golgi apparatus membrane {ECO:0000269PubMed:10444376}; Single-pass membrane protein {ECO:0000269PubMed:10444376}. Endoplasmic reticulum membrane {ECO:0000269PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269PubMed:10444376}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005537	mannose binding
GO:0030246	carbohydrate binding
GO:0031072	heat shock protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0015031	protein transport
GO:0050766	positive regulation of phagocytosis

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0070062	extracellular vesicular exosome