Version 5.4
Homo sapiens Gene: LMAN2
Summary
InnateDB Gene IDBG-59804.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LMAN2
Gene Name lectin, mannose-binding 2
Synonyms C5orf8; GP36B; VIP36
Species Homo sapiens
Ensembl Gene ENSG00000169223
Encoded Proteins
IDBP-59806
lectin, mannose-binding 2
IDBP-484421
lectin, mannose-binding 2
IDBP-483957
lectin, mannose-binding 2
IDBP-476330
lectin, mannose-binding 2
IDBP-477404
lectin, mannose-binding 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177331562-177351852
Strand Reverse strand
Band q35.3
Transcripts
ENST00000303127 ENSP00000303366
ENST00000504071
ENST00000515209 ENSP00000423998
ENST00000514458 ENSP00000424132
ENST00000502560 ENSP00000425229
ENST00000502721
ENST00000513877 ENSP00000427377
ENST00000506310
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005537 mannose binding
GO:0030246 carbohydrate binding
GO:0031072 heat shock protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0015031 protein transport
GO:0050766 positive regulation of phagocytosis
Cellular Component
GO:0000139 Golgi membrane
GO:0005615 extracellular space
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021484
View Gene Order
ENSBTAG00000008034
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006816
HUGO
OMIM
CCDS CCDS4417
HPRD 17285
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca