InnateDB Protein
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IDBP-598106.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NEIL2
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Protein Name
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nei endonuclease VIII-like 2 (E. coli)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000435657
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InnateDB Gene
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IDBG-7513 (NEIL2)
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Protein Structure
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Function |
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. {ECO:0000269PubMed:12097317, ECO:0000269PubMed:14522990, ECO:0000269PubMed:15175427, ECO:0000269PubMed:15339932}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12097317}.
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Disease Associations |
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Tissue Specificity |
Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver. {ECO:0000269PubMed:12097317}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000214
Zinc finger, DNA glycosylase/AP lyase-type
IPR010979
Ribosomal protein S13-like, H2TH
IPR015886
DNA glycosylase/AP lyase, H2TH DNA-binding
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PFAM |
PF06831
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q969S2
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PhosphoSite |
PhosphoSite-Q969S2
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TrEMBL |
Q3ZCR7
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UniProt Splice Variant |
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Entrez Gene |
252969
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UniGene |
Hs.293818
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RefSeq |
NP_001129220
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HUGO |
HGNC:18956
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OMIM |
608933
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CCDS |
CCDS47802
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HPRD |
16406
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IMGT |
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EMBL |
AB079070
AC069185
AK056206
AK097389
AK294224
AY306127
BC013952
BC013964
BC045822
BX537529
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GenPept |
AAH13952
AAH13964
AAH45822
AAP45052
BAB71120
BAC05030
BAC06478
BAG57528
CAD97774
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