Version 5.4
Homo sapiens Protein: ELOVL5
Summary
InnateDB Protein IDBP-598582.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELOVL5
Protein Name ELOVL fatty acid elongase 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000440728
InnateDB Gene IDBG-90996 (ELOVL5)
Protein Structure
UniProt Annotation
Function Condensing enzyme that catalyzes the synthesis of monounsaturated and of polyunsaturated very long chain fatty acids Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. {ECO:0000269PubMed:10970790, ECO:0000269PubMed:20937905}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:20937905}; Multi-pass membrane protein {ECO:0000269PubMed:20937905}.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. {ECO:0000269PubMed:10970790, ECO:0000269PubMed:20937905}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0009922 fatty acid elongase activity
Biological Process
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0019432 triglyceride biosynthetic process
GO:0033559 unsaturated fatty acid metabolic process
GO:0034625 fatty acid elongation, monounsaturated fatty acid
GO:0034626 fatty acid elongation, polyunsaturated fatty acid
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0036109 alpha-linolenic acid metabolic process
GO:0042761 very long-chain fatty acid biosynthetic process
GO:0043651 linoleic acid metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002076 GNS1/SUR4 membrane protein
PFAM PF01151
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NYP7
PhosphoSite PhosphoSite-Q9NYP7
TrEMBL
UniProt Splice Variant
Entrez Gene 60481
UniGene Hs.741463
RefSeq NP_001229759
HUGO HGNC:21308
OMIM 611805
CCDS CCDS75470
HPRD 13268
IMGT
EMBL AB209798 AF111849 AF231981 AF338241 AK074748 AK074889 AK302948 AL034374 AL136939 BC017270 BC067123 BC074503 CH471081
GenPept AAF16688 AAF70631 AAH17270 AAH67123 AAM00193 BAC11178 BAC11270 BAD93035 BAG64104 CAB66873 CAI21530 CAI21531 EAX04419

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca