InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRF1

Summary

InnateDB Protein

IDBP-598652.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRF1

Protein Name

BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)

Synonyms

BRF; BRF-1; GTF3B; hBRF; HEL-S-76p; TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90;

Species

Homo sapiens

Ensembl Protein

ENSP00000448323

InnateDB Gene

IDBG-23236 (BRF1)

Protein Structure

UniProt Annotation

Function

General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0017025	TBP-class protein binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0006384	transcription initiation from RNA polymerase III promoter
GO:0009303	rRNA transcription
GO:0009304	tRNA transcription
GO:0010467	gene expression
GO:0043488	regulation of mRNA stability
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0000126	transcription factor TFIIIB complex
GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000812 Transcription factor TFIIB
IPR011665 Brf1, TBP-binding domain
IPR013137 Zinc finger, TFIIB-type
IPR013150 Transcription factor TFIIB, cyclin-like domain
IPR013763 Cyclin-like

PFAM

PF07741
PF08271
PF00382

PRINTS

PR00685

PIRSF

SMART

SM00385

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt