Version 5.4
Homo sapiens Gene: BRF1
Summary
InnateDB Gene IDBG-23236.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRF1
Gene Name BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
Synonyms BRF; BRF-1; GTF3B; hBRF; HEL-S-76p; TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90
Species Homo sapiens
Ensembl Gene ENSG00000185024
Encoded Proteins
IDBP-23238
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-23240
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-23244
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-245396
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-378565
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-378580
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-598652
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-584519
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-584634
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-586178
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-601604
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-584731
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-584154
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-590831
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-592472
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-583188
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-588919
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
IDBP-811469
BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:105209286-105315589
Strand Reverse strand
Band q32.33
Transcripts
ENST00000327359 ENSP00000329029
ENST00000379937 ENSP00000369269
ENST00000379932 ENSP00000369264
ENST00000392557 ENSP00000376340
ENST00000446501 ENSP00000389859
ENST00000440513 ENSP00000388877
ENST00000546474 ENSP00000448323
ENST00000547374
ENST00000547530 ENSP00000448387
ENST00000551787 ENSP00000446901
ENST00000546997
ENST00000549044
ENST00000547562 ENSP00000450151
ENST00000547052
ENST00000549655 ENSP00000448723
ENST00000552127 ENSP00000449788
ENST00000546417 ENSP00000450258
ENST00000550208 ENSP00000449173
ENST00000550375 ENSP00000447521
ENST00000550692 ENSP00000448823
ENST00000548421 ENSP00000446707
ENST00000619151 ENSP00000480452
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0017025 TBP-class protein binding
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006383 transcription from RNA polymerase III promoter
GO:0006384 transcription initiation from RNA polymerase III promoter
GO:0009303 rRNA transcription
GO:0009304 tRNA transcription
GO:0010467 gene expression
GO:0043488 regulation of mRNA stability
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000126 transcription factor TFIIIB complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000011158
View Gene Order
ENSBTAG00000012753
Not yet available
Pathways
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_1036
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_347
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q92994
TrEMBL B3KWA2 F8VQ19
UniProt Splice Variant
Entrez Gene 2972
UniGene Hs.424484 Hs.666124
RefSeq NM_001242789 NM_001242786 NM_001242787 NM_001242788 NM_001242790 NM_001519 NM_145685 XM_005267561 XM_005267563 XM_006720122
HUGO HGNC:11551
OMIM 604902
CCDS CCDS55949 CCDS10001 CCDS42001 CCDS55950 CCDS55951 CCDS55952 CCDS55953
HPRD 05361
IMGT
EMBL AJ297406 AJ297407 AJ297408 AK096471 AK124665 AK294899 AK295579 AL512355 BC016743 BC071637 BC086856 BC103859 CH471061 U28838 U75276
GenPept AAB38876 AAC50170 AAH16743 AAH71637 AAH86856 AAI03860 BAG53298 BAG54064 BAG58477 BAH11919 CAC04512 CAC04513 CAC04514 EAW81908 EAW81911
RNA Seq Atlas 2972

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca