InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V0B

Summary

InnateDB Protein

IDBP-598699.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0B

Protein Name

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

Synonyms

ATP6F; HATPL; VMA16;

Species

Homo sapiens

Ensembl Protein

ENSP00000431605

InnateDB Gene

IDBG-97633 (ATP6V0B)

Protein Structure

UniProt Annotation

Function

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Vacuole membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0005774	vacuolar membrane
GO:0010008	endosome membrane
GO:0030670	phagocytic vesicle membrane
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179	proton-transporting V-type ATPase, V0 domain