Version 5.4
| Homo sapiens Gene: ATP6V0B | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-97633.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | ATP6V0B | ||||||||||||||||||
| Gene Name | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | ||||||||||||||||||
| Synonyms | ATP6F; HATPL; VMA16 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000117410 | ||||||||||||||||||
| Encoded Proteins |
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008] This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:43974487-43978295 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p34.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Transferrin endocytosis and recycling pathway
Iron uptake and transport pathway
Insulin receptor recycling pathway
Signaling by Insulin receptor pathway
Phagosomal maturation (early endosomal stage) pathway
Transmembrane transport of small molecules pathway
Signal Transduction pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
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| KEGG |
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Oxidative phosphorylation pathway
Lysosome pathway
Phagosome pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q99437 | ||||||||||||||||||
| TrEMBL | E9PKB6 E9PMR1 E9PNL3 E9PNU0 Q8NHD8 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 533 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_001039457 NM_001294333 NM_004047 XM_005270944 | ||||||||||||||||||
| HUGO | HGNC:861 | ||||||||||||||||||
| OMIM | 603717 | ||||||||||||||||||
| CCDS | CCDS41315 CCDS505 CCDS72772 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB045777 AL357079 BC000423 BC005876 BT007151 CH471059 CR456972 D89052 | ||||||||||||||||||
| GenPept | AAH00423 AAH05876 AAP35815 BAA13753 BAC02927 CAG33253 CAI16801 EAX07066 EAX07067 EAX07068 | ||||||||||||||||||
| RNA Seq Atlas | 533 | ||||||||||||||||||