InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SULT2A1

Summary

InnateDB Protein

IDBP-59886.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT2A1

Protein Name

sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1

Synonyms

DHEA-ST; DHEAS; HST; hSTa; ST2; ST2A1; ST2A3; STD;

Species

Homo sapiens

Ensembl Protein

ENSP00000222002

InnateDB Gene

IDBG-59884 (SULT2A1)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008146	sulfotransferase activity
GO:0047704	bile-salt sulfotransferase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0007586	digestion
GO:0008202	steroid metabolic process
GO:0030573	bile acid catabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923	sulfation