InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FUT6

Summary

InnateDB Protein

IDBP-599071.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FUT6

Protein Name

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

Synonyms

FCT3A; FT1A; Fuc-TVI; FucT-VI;

Species

Homo sapiens

Ensembl Protein

ENSP00000432954

InnateDB Gene

IDBG-20780 (FUT6)

Protein Structure

UniProt Annotation

Function

Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Disease Associations

Tissue Specificity

Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008417	fucosyltransferase activity
GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
GO:0046920	alpha-(1->3)-fucosyltransferase activity

Biological Process

GO:0006486	protein glycosylation
GO:0036065	fucosylation
GO:0042355	L-fucose catabolic process

Cellular Component

GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome