Version 5.4
Homo sapiens Gene: FUT6
Summary
InnateDB Gene IDBG-20780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUT6
Gene Name fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
Synonyms FCT3A; FT1A; Fuc-TVI; FucT-VI
Species Homo sapiens
Ensembl Gene ENSG00000156413
Encoded Proteins
IDBP-8274
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
IDBP-20782
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
IDBP-601472
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
IDBP-599071
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
IDBP-590899
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
IDBP-594517
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
IDBP-595953
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
IDBP-599068
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
IDBP-593014
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
IDBP-759840
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5830610-5839731
Strand Reverse strand
Band p13.3
Transcripts
ENST00000318336 ENSP00000313398
ENST00000286955 ENSP00000286955
ENST00000524754 ENSP00000431708
ENST00000527106 ENSP00000432954
ENST00000529165 ENSP00000436547
ENST00000531085 ENSP00000432161
ENST00000531199 ENSP00000436413
ENST00000532464 ENSP00000431880
ENST00000528505 ENSP00000433811
ENST00000526499
ENST00000591079
ENST00000592563 ENSP00000466016
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008417 fucosyltransferase activity
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
GO:0046920 alpha-(1->3)-fucosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0036065 fucosylation
GO:0042355 L-fucose catabolic process
Cellular Component
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa00601
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631846 Hs.705615
RefSeq NM_000150 NM_001040701 XM_005259526
HUGO
OMIM
CCDS CCDS12152
HPRD 00651
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca